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Huge positive news on the effort to create a coronavirus vaccine
Pfizer has announced early data in its vaccine trial that indicates an efficacy of 90%! The news could...
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Aztrazenica vaccine releases interim data showing good immune responses across all ages
AstraZeneca announced today that their candidate SARS-CoV-2 vaccine was creating a strong immune response...
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The UW is succeeding at fighting the COVID-19 epidemic
While much of Wisconsin is failing at fighting the coronavirus, the Universities are succeeding. Dr....
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Vaccines are progressing and a new, potentially powerful treatment for SARS-CoV-2
SARS-CoV-2 Vaccines Vaccines by Moderna, Pfizer, and AstraZeneca continue to make progress in their...
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How to beat COVID-19
It was not on purpose, but Dane County did a good experiment that shows how simple public health measures...
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A topoisomerase I mutation is lethal, the definative paper.

  Topoisomerase I unwinds the DNA during cell replication and is an enzyme that is found in Archaea, Bacteria, and Eukarya. Most every living thing has a homolog. To everyone's surprise, it is possible to create mutations that completely remove the activity of the enzyme, yet have cells capable of growth. These cells are sick, but they can grow. The latest research by Stockum et al. shows that these deletion mutants of topoisomerase I actually have compensating mutations, and in fact loss of topoi...

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Norvirus, resistance is futile. Well, maybe not

  Norovirus is a nasty little virus that causes tons of misery every winter. It is an RNA virus that infects the gastrointestinal tract causing violent vomiting and diarrhea. About 12 to 48 hours after being infected, rapid symptom onset will lay you flat for about a day. Even better, immunity to this virus fades in a few months and you are susceptible to a new attack. A particularly nasty strain of norovirus has been circulating in my area and my family came down with it just this weekend. The vi...

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