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The very real danger of alfatoxins
Food products, especially harvested grains, need to be stored carefully. Proper management means storing...
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The 6th Edition of Through the Microscope is now available
The website, eBooks, and hard copy of Through the Microscope are now available. To purchase website access,...
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The stringent response can influence antibiotic resistance
Cancer is a horrible disease, killing over half a million people in the United States every year and...
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Gut disbiosys hinders the healing of spinal cord injuries
There has been a growing body of evidence that the microorganisms that live with us on our bodies deeply...
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A new avenue of attack against drug resistance pathogens
Some pathogens are becoming resistant to many of the treatments we have for them. It is serious enough...
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A topoisomerase I mutation is lethal, the definative paper.

  Topoisomerase I unwinds the DNA during cell replication and is an enzyme that is found in Archaea, Bacteria, and Eukarya. Most every living thing has a homolog. To everyone's surprise, it is possible to create mutations that completely remove the activity of the enzyme, yet have cells capable of growth. These cells are sick, but they can grow. The latest research by Stockum et al. shows that these deletion mutants of topoisomerase I actually have compensating mutations, and in fact loss of topoi...

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Norvirus, resistance is futile. Well, maybe not

  Norovirus is a nasty little virus that causes tons of misery every winter. It is an RNA virus that infects the gastrointestinal tract causing violent vomiting and diarrhea. About 12 to 48 hours after being infected, rapid symptom onset will lay you flat for about a day. Even better, immunity to this virus fades in a few months and you are susceptible to a new attack. A particularly nasty strain of norovirus has been circulating in my area and my family came down with it just this weekend. The vi...

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